Where is coq10 found in the body

CoQ10 is found throughout the body in cell membranes, especially in the mitochondrial membranes, and is chiefly abundant in the heart, lungs, liver, kidneys, spleen, pancreas, and adrenal glands.

The whole body content of CoQ10 is only about mg and decreases with age. Coenzyme Q10 is one of the most significant lipid antioxidants that prevents the generation of free radicals and modifications of proteins, lipids, and DNA. National Center for Biotechnology Information , U. J Pharm Bioallied Sci. Rajiv Saini. Author information Copyright and License information Disclaimer. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.

This article has been cited by other articles in PMC. Sir, Coenzyme Q CoQ or Ubiquinone is a naturally occurring quinone that is found in most aerobic organisms from bacteria to mammals. References 1. Elevated hydroperoxide levels and antioxidant patterns in Papillon-Lefevre syndrome.

J Periodontol. Oxidative injury and inflammatory periodontal diseases: The challenge of antioxidants to free radicals and reactive oxygen species. Crit Rev Oral Biol Med. However, because coenzyme Q 10 circulates with lipoproteins , plasma coenzyme Q 10 concentration is influenced by the concentration of circulating lipids , It is likely that circulating coenzyme Q 10 concentrations are decreased because statins reduce circulating lipids rather than because they inhibit coenzyme Q 10 synthesis In addition, very few studies have examined coenzyme Q 10 concentrations in tissues other than blood such that the extent to which statin therapy affects coenzyme Q 10 concentrations in the body's tissues is unknown , , Finally, there is currently little evidence to suggest that secondary coenzyme Q 10 deficiency is responsible for statin-associated muscle symptoms in treated patients.

In addition, supplementation with coenzyme Q 10 failed to relieve myalgia in statin-treated patients see Disease Treatment , Originally written in by: Jane Higdon, Ph. Updated in February by: Victoria J. Drake, Ph. Updated in March by: Victoria J. Updated in April by: Barbara Delage, Ph. Reviewed in May by: Roland Stocker, Ph. Coenzyme Q biosynthesis in health and disease. Biochim Biophys Acta.

Crane FL. Biochemical functions of coenzyme Q J Am Coll Nutr. Nohl H, Gille L. The role of coenzyme Q in lysosomes. The importance of plasma membrane coenzyme Q in aging and stress responses. Ernster L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Thomas SR, Stocker R. Mechanisms of antioxidant action of ubiquinol for low-density lipoprotein.

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance. Independent and concerted antioxidant functions of coenzyme Q. Coenzyme Q10 in health and disease. Eur J Clin Nutr. Hargreaves IP. Coenzyme Q10 as a therapy for mitochondrial disease. Int J Biochem Cell Biol. Coenzyme Q10 defects may be associated with a deficiency of Qindependent mitochondrial respiratory chain complexes.

Biol Res. Age-related changes in the lipid compositions of rat and human tissues. Coenzyme Q10 Supplementation in Aging and Disease. Front Physiol. Mitochondrial aging: open questions. Ann N Y Acad Sci. Effect on absorption and oxidative stress of different oral Coenzyme Q10 dosages and intake strategy in healthy men.

Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice. Free Radic Biol Med. Lapointe J, Hekimi S. J Biol Chem. Supplementation with the reduced form of coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice.

Mol Nutr Food Res. Ubiquinol supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice. Antioxid Redox Signal. Improved health-related quality of life, and more days out of hospital with supplementation with selenium and coenzyme Q10 combined. Results from a double-blind, placebo-controlled prospective study.

J Nutr Health Aging. Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly. PLoS One. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation.

Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice. Dietary cosupplementation with vitamin E and coenzyme Q 10 inhibits atherosclerosis in apolipoprotein E gene knockout mice.

Arterioscler Thromb Vasc Biol. Biochem Biophys Res Commun. Neuromuscul Disord. The myopathic form of coenzyme Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein dehydrogenase ETFDH gene. Coenzyme Q 10 -responsive ataxia: 2-year-treatment follow-up.

Mov Disord. Effects of coenzyme Q10 on statin-induced myopathy: a meta-analysis of randomized controlled trials. Mayo Clin Proc. Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation. Nutr Rev. Congestive heart failure. Rakel: Conn's Current Therapy New York: W.

Saunders Company; Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA controlled rosuvastatin multinational study in heart failure. J Am Coll Cardiol. Coenzyme Q10 for heart failure. Cochrane Database Syst Rev. Lei L, Liu Y. Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials. BMC Cardiovasc Disord. Cardiovasc Res. Coenzyme Q10 regulates antioxidative stress and autophagy in acute myocardial ischemia-reperfusion injury.

Oxid Med Cell Longev. The effects of ageing on the response to cardiac surgery: protective strategies for the ageing myocardium.

Overview of the use of CoQ10 in cardiovascular disease. The role of oral coenzyme Q10 in patients undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. Effects of short-term supplementation with coenzyme Q10 on myocardial protection during cardiac operations.

Ann Thorac Surg. Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: a randomised trial. Heart Lung Circ. Celik T, Iyisoy A. Coenzyme Q10 and coronary artery bypass surgery: what we have learned from clinical trials. High plasma coenzyme Q10 concentration is correlated with good left ventricular performance after primary angioplasty in patients with acute myocardial infarction. Medicine Baltimore. The randomized clinical trial of coenzyme Q10 for the prevention of periprocedural myocardial injury following elective percutaneous coronary intervention.

Cardiovasc Ther. Role of coenzyme Q10 in chronic heart failure, angina, and hypertension. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension.

The effects of coenzyme Q10 supplementation on blood pressures among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials.

High Blood Press Cardiovasc Prev. Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials. Effects of coenzyme Q10 supplementation on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. Effects of coenzyme Q10 supplementation on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials.

Effects of coenzyme Q10 on markers of inflammation: a systematic review and meta-analysis. Supplementation with coenzyme Q10 reduces plasma lipoprotein a concentrations but not other lipid indices: A systematic review and meta-analysis. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis.

J Clin Pharm Ther. Effect of long-term treatment with antioxidants vitamin C, vitamin E, coenzyme Q10 and selenium on arterial compliance, humoral factors and inflammatory markers in patients with multiple cardiovascular risk factors. Nutr Metab Lond. Clin Chim Acta. Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q Diabet Med.

Maternal transmission of diabetes. The effects of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA A to G mutation.

Henchcliffe C, Beal MF. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol. Altered redox state of platelet coenzyme Q10 in Parkinson's disease.

J Neural Transm. Ann Neurol. Neurosci Lett. The coenzyme Q10 status of the brain regions of Parkinson's disease patients. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline.

Arch Neurol. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. JAMA Neurol. Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q10 for Parkinson's disease.

Parkinsonism Relat Disord. Coenzyme Q10 for patients with Parkinson's disease: a systematic review and meta-analysis. The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials. Neurol Sci. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

J Neurosci. Scientists have identified associations between CoQ10 deficiency and heart disease and cancer. However, it might help treat certain heart conditions and prevent migraines. Researchers have also looked at the effects of CoQ10 on a variety of other conditions, but the results are inconclusive.

CoQ10 might help treat specific heart conditions, such as congestive heart failure and high blood pressure , particularly among older individuals. Research on the effectiveness of CoQ10 for heart problems has provided mixed results. However, one study reported that CoQ10 was an important factor in the survival of older adults with chronic heart failure. Other research showed that CoQ10 might help people recover from some types of heart surgery.

According to both the American Academy of Neurology and the American Headache Society, CoQ10 may be effective in preventing migraines, although the research to support this is still limited. It is possible that CoQ10 has this effect because it keeps the mitochondria in the cells healthy. Some research suggests that CoQ10 might help ease muscle weakness that is due to taking cholesterol-lowering medications, known as statins.

However, the results of another trial showed that treatment with CoQ10 did not reduce muscle pain in people who were also using statins to control their cholesterol levels. People can obtain CoQ10 by eating certain meats and grain proteins, but the quantity present in these foods is too small to increase CoQ10 levels in the body significantly. CoQ10 supplements are available to take either by intravenous IV injection or as capsules or tablets.

Studies have used daily doses of CoQ10 ranging from 50 milligrams mg to 1, mg in adults. A typical daily dose for someone who has a CoQ10 deficiency is — mg , while the observed safe level is 1, mg per day.

Studies have shown a significant reduction in plasma CoQ10 concentrations following treatment with statins. Additionally, CoQ10 may reduce the effectiveness of blood-thinning drugs, such as warfarin, and this may increase the risk of blood clots.

CoQ10 may also interfere with insulin and some chemotherapy medications. Coenzyme Q10 CoQ10 is a naturally occurring antioxidant that is present in almost every cell in the human body. Scientists have linked low levels of CoQ10 with various medical conditions, including heart disease and cancer.

People usually tolerate CoQ10 supplementation well, and the supplements produce few, if any, side effects.